The new immunotherapy drugs that have worked so well in cancers like melanoma are so far not helping much in breast cancer.
A protein in the body called PERK may play a part in stopping immunotherapies from working in advanced breast cancer. Dr Dean Singleton at the University of Auckland will investigate whether suppressing PERK can improve immune responses in models of breast cancer, and whether an anti-PERK drug could be delivered directly to a breast tumour, where it could enable immunotherapy drugs to work.